Purpose This reaction involves nucleophilic attack by the alkene on bromine, forming a tertiary carbocation with bromonium ion character. Biophys. Jiang, S. Y. et al. Mol. SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression. In agreement with Schwenk and Werthessen, a single bromination and reconversion to cholesterol was usually sufficient to establish radiochemical purity of the isolated sterol. NiemannPick C1 like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis. Liver Physiol. Yu, L. Q. et al. Rodgers, J. T. & Puigserver, P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. 282, 2743627446 (2007). A class of naturally occurring organic compounds that are composed of two or more unitsof isoprene. Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1. Liver Physiol. A. Nucleophile B. Solvent C. byproduct D. electrophile 3. Sci. 22, 422429 (2010). & Brown, A. J. Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase. Quantitative gas-solid addition of bromine to cholesterol and the Kobayashi, A. et al. Arterioscler. Nature 534, 124128 (2016). FEBS Lett. Natl Acad. Google Scholar. Sci. Small, D. M. Role of ABC transporters in secretion ofcholesterol from liver into bile. & Dietschy, J. M. Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1. (LXRs). Li, P. S. et al. Bromination is a chemical reaction involving the reaction of a compound, and bromine results in bromine being added to the compound. Yue, S. H. et al. Google Scholar. Curr. Genet. Genet. Mol. J. Biol. Proc. Sci. J. Biol. et al. Sorrentino, V. et al. Calkin, A. C. et al. 47, 17911802 (2006). The Bromination of Cholesterol, An Electrophilic Addition Reaction of a Natural Product lab report University Massachusetts College of Pharmacy and Health Sciences Course Organic Chemistry I (CHE 231) 132 Documents Academic year:2018/2019 TT Uploaded byThao Tran Helpful? Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. eLife 6, e28766 (2017). The interface formed between an antigen-presenting cell or target cell and a lymphocyte such as a T cell, B cell or natural killer cell. Chem. A. Liver Physiol. Cell 171, 10941109 (2017). Insulin induces human acyl-coenzyme A:cholesterol acyltransferase1 gene expression via MAP kinases and CCAAT/enhancer-binding protein . J. PubMed 59, 749763 (2018). Sano, O. et al. Biochim. 62, 11171135 (2019). ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. Cell 110, 489500 (2002). 274, 3613936145 (1999). Li, T. et al. Schumacher, M. M., Jun, D. J., Jo, Y., Seemann, J. Nat. Am. J. Luo, J., Yang, H. & Song, BL. Malhotra, P. et al. Rosenson, R. S. et al. Glerup, S., Schulz, R., Laufs, U. Cell Metab. Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP. Biochem. Natl Acad. Atherosclerosis 281, 137142 (2018). 286, 2508825097 (2011). Trends Biochem. Vasc. Edit 2 I remembered some brominations on dimethoxy-substituted hydroxymethylnaphthalines I did back in the days. A. 278, 5247952490 (2003). CAS The spherical assembly ofamphiphilic molecules dispersed in water solvent. J. Biol. (ERC). J. Lipid Res. J. Biol. Med. Mutations in NPC1 cause 95%of NPC cases. Science 274, 255259 (1996). Commun. Jakulj, L. et al. Blom, D. J. et al. Adi, D. et al. Debromination - an overview | ScienceDirect Topics
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